Antonio Sanabria and Omar Alderete scored either side of halftime as Paraguay recovered from a goal down to clinch a 2-1 home win over Argentina
Inter Milan striker Lautaro Martinez put the visitors ahead when he ran onto Enzo Fernandez's chipped pass and showed deft control before slotting a low shot into the far corner.
Sanabria equalized with a superb overhead volley following a Gustavo Velazquez cross from the right flank.
The hosts took the lead just after halftime through Alderete, who headed home after Diego Gomez's floating free-kick.
Despite the result, Argentina remain top of the 10-team South American zone standings with 22 points from 11 qualifiers, six points ahead of Paraguay.
The top six teams will automatically qualify for the 2026 World Cup in the United States, Mexico and Canada while the seventh-ranked side will advance to an intercontinental playoff.